M.H. Oztop, and K.L. McCarthy
University of California, Davis, CA, USA
In this study, Whey Protein Isolate (WPI) gels of different thickness were soaked in solutions of pH 7.0 and mass uptake was recorded. A finite element model based on diffusion and deformed mesh application modes in COMSOL Multiphysics was developed. Deformed mesh application mode provided the opportunity to incorporate the moving boundaries. The moving boundaries were solved by introducing ...
Modeling Antibiotic Diffusion in a Microfluidic Biofilm Array to Study Bacterial Responses to Antibiotic Concentrations and Combinations
J. Deng, L. Villegas, L. Shor, A. Vázquez, A. Dhummakupt, P. Samson, and J.P. Wikswo
University of Connecticut, Storrs, CT, USA
Instituto Tecnológico y de Estudios Superiores de Monterrey, Monterrey, Mexico
Vanderbilt University, Nashville, TN, USA
Bacteria within a biofilm typically exhibit higher resistance to antibiotic therapy due to mass transport resistance of the biofilm matrix and/or reduced metabolic activity of cells living within the biofilm interior. The objective of this research was to develop a high-throughput experimental and modeling approach to investigate the effects of colony spacing and concentration on the ...
T. Merrill, and A. La Barck
Rowan University, Glassboro, NJ, USA
Reperfusion injury is caused by the rapid restoration of blood flow to oxygen-starved tissue. The model will simulate pulsatile blood flow. A separate 2-dimensional axisymmetric straight tube model will be constructed to simulate the pulsating angioplasty balloon within the flow path. Outlet flow profiles from the straight tube model will then be used as the inlet condition for the ...