Technical Papers and Presentations

The developments of microsystems for biotechnology have been fast in the last few years, and no sign of slowing down is observed. It has begun with lab-on-chip for genomics, especially for the recognition of DNA sequences, followed by protein reactors and immunoassays, and today the emphasis is on cellomics.

Cell-chips are design to monitor the behavior of cells, individually or as a group, and to estimate parameters such as cell signals, cell response to drugs, and cellular differentiation. In this paper, we present some examples of cell manipulation in chips—which is often called cellular biomicrofluidics—and cell-chips, and show how their functioning and numerical simulation and COMSOL in particular can contribute to their design.