M. Carfagna , A. Grillo ,
 Dipartimento di Scienze Matematiche, Politecnico di Torino, Italy
The numerical results of the unconfined compression test on a sample of Articular Cartilage (AC) are discussed. AC is modelled as a load-bearing, deformable, fiber-reinforced material filled with an interstitial fluid and comprising statistically oriented collagen fibers, chondrocytes, and a matrix of proteoglycans. A strain energy is assigned to characterize the mechanical behavior of the ...
H. Chen-Mayer, R.E. Tosh
National Institute of Standards and Technology, Gaithersburg, MD, USA
The radiation dose produced by an x-ray CT scanner to the patient is conventionally referenced to measurements performed by an ionization chamber in a phantom. On a fundamental level, the radiation absorbed dose, J/kg, can be determined directly by the temperature rise in the absorbing material. We model the temperature response in a high density polyethylene (HDPE) phantom. Use of ...
R. Sikorski, B. Chapman, T. Merrill
Rowan University, Glassboro, NJ, USA
A CFD cardiac catheter model was developed to determine the potential for blood hemolysis during administration of local therapeutic hypothermia using a CoolGuide catheter. In vivo animal studies have shown that mild hypothermia may reduce reperfusion injury often associated with heart attack. The CoolGuide Catheter System (CCS) delivers rapid local cooling through a cardiac catheter, reducing ...
J. Martel, N. Elabbasi, D. Quinn, J. Bergstrom, M. Toner
BioMEMS Resource Center, Massachusetts General Hospital, Boston, MA, USA
Veryst Engineering, Needham, MA, USA
Inertial focusing is a promising microfluidic technique for separating and concentrating cells of interest, processes routinely utilized in many medical procedures. This phenomenon is characterized by suspended particles in a flow spontaneously migrating across streamlines to equilibrium positions within a channel cross-section. We developed CFD models in COMSOL Multiphysics® to predict the ...
Comparison of Finite Element and Monte Carlo Simulations for Inhomogeneous Advanced Breast Cancer Imaging
Y. Xu, and Q. Zhu
University of Connecticut, Storrs, CT, USA
Three-dimensional FEM method provided by COMSOL is used to model an inhomogeneous advanced breast tumor of different optical properties for outer layer and inner core in a semi-infinite medium. The running time of FEM by COMSOL for one source and 14 detectors is 17.658s and which of Monte Carlo (MC) is 91017s, 5154 times longer. The absorption distribution is reconstructed by born approximation. ...
J. Persad , S. Rocke , D. Ringis , A. Abdool ,
 Department of Electrical and Computer Engineering, University of the West Indies, St. Augustine, Trinidad and Tobago
3D printing as applied to the area of electronics manufacture covers a broad range of traditional printing technologies . The attraction in 3D printing lies in its potential to disrupt the traditional photolithographic/subtractive manufacturing line with simpler additive processes. Additive electronics manufacturing which utilises 3D printing techniques allow for fewer production steps and ...
T. Maguire [1,2], M. Davis , I. Marrero-Berrios , C. Zhu , C. Gaughan , J. Weinberg , D. Manchikalapati , J. SchianodiCola , R. S. Schloss , J. Yarmush , M. Yarmush ,
 Rutgers University, New Brunswick, NJ, USA
 BeauRidge Pharmaceuticals, New York, NY, USA
 Department of Anesthesiology, New York Methodist Hospital, Brooklyn, NY, USA
Introduction: While general anesthetics control pain via consciousness regulation, local anesthetics (LAs) act by decreasing sensation in the area of administration by blocking nerve transmission to pain centers. Perioperative intra-articular administration of LAs is a commonly employed procedure in orthopedic procedures to minimize patient surgical and post-surgical pain. LAs are also co ...
A Multiscale-Multiphysics Model for Axon Pathfinding Simulation, the Example of the Olfactory System
G. Naldi, G. Aletti, P. Causin
Dipartimento di Matematica ‘F. Enriques’, Università degli Studi di Milano, Milano, Italy
In the developing embryo, neurons form connections by projecting axons to appropriate target areas. The projection process includes neurite elongation, resulting from the assembly of new cytoskeletal material at the free end of the axon, a complex cascade of steering decisions, driven by biomechanical properties of the surrounding environment and by signals in it. In this work we focus on the ...
Electro Thermal Performance Prediction of Radio Frequency Ablation System for Efficient Cancer Treatment
C. Thiagarajan, V. Gnanasekar
ATOA Scientific Technologies Pvt Ltd, Whitefield, Bangalore, Karnataka, India.
Perfint Healthcare Pvt. Ltd, T.Nagar, Chennai, India.
Cancer causes significant human deaths. Radiofrequency ablation is an encouraging procedure for cancer treatment. The objective is to demonstrate the multiphysics simulation methodology. This paper summarizes the problem , governing equations, methodology, assumptions, simulation results and discussion related to the thermal performance prediction of radio frequency ablation on a homogeneous ...
J.Borana, J.M.Lee, B.G.Chung
Indian Institute of Technology Guwahati, Guwahati, India
Department of Mechanical Engineering, Sogang University, Seoul, Korea
We developed the dual-micropillar-based microfluidic platform to control cellular behavior. The 4×4 dual micro-pillar based platform consists of 16 circular-shaped outer micropillars and 8 saddle shaped inner-micropillars. We simulated various shapes of inner micropillars to analyze the shear stress inside the inner micropillar. Therefore, this dual-micropillar-based microfluidic platform could ...