Here you will find presentations given at COMSOL Conferences around the globe. The presentations explore the innovative research and products designed by your peers using COMSOL Multiphysics. Research topics span a wide array of industries and application areas, including the electrical, mechanical, fluid, and chemical disciplines. Use the Quick Search to find presentations pertaining to your application area.

Modeling Interface Response in Cellular Adhesion

G. Megali[1], D. Pellicanò[1], M. Cacciola[1], F. Calarco[1], D. De Carlo[1], F. Laganà[1], and F.C. Morabito[1]

[1]DIMET Department, Faculty of Engineering, University “Mediterranea” of Reggio Calabria, Reggio Calabria, Italy

Constitutive properties of living cells are able to withstand physiological environment as well as mechanical stimuli occurring within and outside the body. We examined fluid flow and Neo-Hookean deformation related to the rolling effect. A mechanical model to describe the cellular adhesion with detachment is here proposed. We developed a finite element analysis, simulating blood cells attached ...

Energy Harvesting from Variation in Blood Pressure through Deformation of Arterial Wall using Electro-magneto-hydrodynamics

A. Pfenniger[1], V.M. Koch[2], A. Stahel[2], and R. Vogel[1]
[1]ARTORG Cardiovascular Engineering, University of Bern, Bern, Switzerland
[2]Bern University of Applied Sciences, Engineering and Information Technology, Biel, Switzerland

The present project aims at modelling a generator that harvests energy from the variation in blood pressure by exploiting the motion of the arterial wall between the diastolic and systolic phase of the cardiac cycle. The concept is to use a highly electrically conductive fluid, which is driven by the motion of the arterial wall within a separate compartment outside the artery. A constant ...

Modeling Arterial Drug Transport From Drug-eluting Stents: Effect of Blood Flow on the Concentration Distribution Close to the Endothelial Surface

F. Bozsak, J.-M. Chomaz, and A. I. Barakat
LadHyX, Ecole Polytechnique
Palaiseau, France

Drug-eluting stents (DES) are commonly used for treating coronary atherosclerosis. Despite the broad effectiveness of DES, ~5% of treated patients experience complications including in-stent restenosis and late-stent thrombosis. Furthermore, drugs used in DES not only inhibit proliferation of smooth muscle cells but also affect re-endothelialization. We have developed a computational model ...

Transport and Concentration of Charged Molecules in a Lipid Membrane - new

S. D. Evans[1], J. S. Roth[1], M. R. Cheetham[1]
[1]University of Leeds, Leeds, UK

Brownian ratchets and electric fields are used for the transport of membrane components. Transport is achieved through the combination of a pattern with free diffusion. We show a good agreement between simulation and experiment, therefore allowing for further optimisation of the ratchets using COMSOL Multiphysics. In addition to the transport device we also introduce the possibility to ...

Kinetics of Proteins in the Blood-Brain Barrier

K. Gandhi [1],
[1] University of California, Riverside, CA, USA

The delivery of chemotherapy for cancer into the central nervous system, in particular the brain, remains a challenge. This results in brain metastases commonly being a cause of death from cancer. Here, we look at the environment of the blood-brain barrier. Then, we explore two proteins (breast cancer resistance protein and p-glycoprotein) that may inhibit the transport of medications (erlotinib ...

Advanced Modeling of a Lung-on-a-Chip Microdevice

M. J. Hancock [1], N. H. Elabbasi [1],
[1] Veryst Engineering, Needham, MA, USA

Organ-on-a-chip microdevices combine microfluidics, MEMS, and biotechnology techniques to mimic the multicellular architectures, tissue-tissue interfaces, physicochemical microenvironments, and vascular perfusion of the body.[1] Such devices are being developed to provide better levels of tissue and organ functionality compared with conventional cell culture systems, and have great potential to ...

Effect of Permeability Diminution in Nutrient Diffusion in Intervertebral Disc

M. A. Chetoui [1], O. Boiron [2], A. Dogui [3], V. Deplano [2],
[1] Université de Monastir, Ecole Nationale D'ingénieurs de Monastir; Ecole centrale Marseille, Marseille, France
[2] Aix-Marseille Université, CNRS, Ecole Centrale, Marseille, France
[3] Université de Monastir, Ecole Nationale D'ingénieurs de Monastir, Marseille, France

Intervertebral discs (IVD) are fibro-cartilages situated between vertebrae providing their joint flexibility. They play a major role in the transmission and absorption of load through the spine. The disc can undergo progressive structural and quantitative changes in its composition and morphology related to mechanical load applied to the spine which can lead to disc degeneration; this disease is ...

Simulations of Microelectrode and Neuron Interfaces Enable Long-Term and High Fidelity Recordings

P. Wijdenes [1], H. Ali [2], N. Syed [3], C. Dalton [2],
[1] Centre for Bioengineering Research and Education, University of Calgary, Calgary, AB, Canada
[2] Department of Electrical and Computer Engineering, Schulich School of Engineering, University of Calgary, Calgary, AB, Canada
[3] Alberta Children's Hospital Research Institute, University of Calgary, Calgary, AB, Canada

Our inability to record single cell activity with high resolution over a long period of time precludes fundamental understanding of nervous system functions, both under normal and pathological conditions. While the fabrication of current micro- and nano-electrodes has advanced our capabilities to perform long-term recordings, this has been at the expense of signal resolution due to low sealing ...

血管对肿瘤的光热疗法的影响

吴淑莲 [1], 李晖 [2], 李志芳 [2],
[1] 福建师范大学,福州,中国
[2] 福建师范大学,福州,中国

引言:激光诱导间质肿瘤热疗法是一种可使生物组织局部地方凝结坏死的肿瘤疾病治疗方法,目前已经用于肝、脑等各部位的肿瘤治疗[1-2]。为了更好地进行肿瘤疾病的治疗,需要实时地对组织的温度和热损伤进行监控,而检测技术很难实现对肿瘤治疗过程的实时监测,故数值计算成为研究光热疗法的有力工具[2-6]。本模型将生物组织光传输的物理场与热传输的物理场相耦合,考虑组织光热参数随温度变化的情况,研究了肿瘤周围含有大动脉的情况时组织的温度分布随时间的变化情况,研究结果对指导临床医学肿瘤治疗有重要意义。 COMSOL Multiphysics® 的软件使用: 几何模型:如图1所示,圆柱代表光源,圆形区域代表肝脏肿瘤,弯曲圆柱代表大血管,大正方体代表肝脏。 PDE 接口和生物传热接口,选择生物组织的热损伤。 结果: 如图2,图3所示,在加热过程中,开始时血管对温度分布几乎无影响,但是随着加热时间变长 ...

3-D Finite Element Modeling of Brain Edema: Initial Studies on Intracranial Pressure Using COMSOL Multiphysics®

X.G. Li[1], H. von Holst[1][2], J. Ho[1], and S. Kleiven[1]

[1]Division of Neuronic Engineering, KTH, Stockholm, Sweden
[2]Department of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden

Brain edema is one of the most common consequences of serious traumatic brain injuries which is usually accompanied with increased Intracranial Pressure (ICP) due to water content increment. A three dimensional finite element model of brain edema is used to study intracranial pressure in this paper. Three different boundary conditions at the end of Cerebral Spinal Fluid (CSF) were used to ...