M. J. Hancock , N. H. Elabbasi ,
 Veryst Engineering, Needham, MA, USA
Organ-on-a-chip microdevices combine microfluidics, MEMS, and biotechnology techniques to mimic the multicellular architectures, tissue-tissue interfaces, physicochemical microenvironments, and vascular perfusion of the body. Such devices are being developed to provide better levels of tissue and organ functionality compared with conventional cell culture systems, and have great potential to ...
Modeling Arterial Drug Transport From Drug-eluting Stents: Effect of Blood Flow on the Concentration Distribution Close to the Endothelial Surface
F. Bozsak, J.-M. Chomaz, and A. I. Barakat
LadHyX, Ecole Polytechnique
Drug-eluting stents (DES) are commonly used for treating coronary atherosclerosis. Despite the broad effectiveness of DES, ~5% of treated patients experience complications including in-stent restenosis and late-stent thrombosis. Furthermore, drugs used in DES not only inhibit proliferation of smooth muscle cells but also affect re-endothelialization. We have developed a computational model ...
Downscale Finite Element Modeling of Aortic Valve Leaflets for In-Situ Estimation of Cell Level Mechanics
R. Buchanan, M. Sacks
Institute for Computational Engineering and Sciences, Department of Biomedical Engineering, University of Texas, Austin, TX, USA
As in all tissues, mechanical forces in the aortic valve (AV) modulate the constituent cell population’s physiology and biosynthetic activity. While advances have been made toward the understanding of this complex multi-scale relationship, the specific role that and extracellular matrix (ECM) coupling plays on the mechanical response of the AV interstitial cell (AVIC) is poorly understood. The ...
B. Liu, T. C. Zhu
Department of Radiation Oncology, School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
Deformable image registration is a form of medical image processing that can provide insights into the development of phenomenon and variation in normal anatomical structure over time. Prior to post-operative pleural photodynamic therapy (PDT), a series of CT scans of lungs will be acquired. During PDT treatment, an infrared navigation system is used to contour the lungs and provide real-time ...
Extending Engineering Simulations to Scientists: Food Safety and Quality Prediction Using COMSOL Multiphysics® and LiveLink™ for Excel®
A. Warning, A. K. Datta
Cornell University, Ithaca, NY, USA
The objective of this study was to develop an easy to use interface in Excel® that connects to not only the solvers in COMSOL Multiphysics®, but also existing databases of food properties, foodborne pathogenic microorganisms kinetics, and chemical kinetics, creating a comprehensive simulation software to predict food safety and quality. The user interface allows the user to select the food, ...
K. A. Bodnyk, G. J. Noble, N. Fitzpatrick, M. J. Allen, K. Stephenoff, R. T. Hart
Department of Biomedical Engineering, The Ohio State University, Columbus, OH, USA
Fitzpatrick Referrals, Godalming, Surrey, United Kingdom
Department of Veterinary Medicine, The Ohio State University, Columbus, OH, USA
The elbow joint in dogs constitutes a complex interaction of three bones, the humerus, radius and ulna. Medial coronoid disease (MCD) is a common cause of lameness in dogs, i.e. fracturing of the most prominent portion of the ulnar joint surface driven in flexion and in pivot against both the humerus and the radius. The cause remains unknown, but prior studies suggest joint incongruency as an ...
N. M. Sundaram, M. Alagappan
PSG College of Technology Coimbatore, Tamil Nadu, India
Cholesterol is an essential lipid for human body. The desired total plasma cholesterol for an individual is less than 5.2 mM (200 mg/dL) and it poses a potential health threat when the level is greater than 6.2 mM (240 mg/dL) . Excessive plasma cholesterol causes poor cardiovascular conditions. The experimental fabrication of nano structured biosensor with advanced materials is more expensive ...
R. Kapuganti , S. Anbazhagan,
 HCL Technologies, Chennai, India.
Drop test simulation is one of the important tool used for the impact behaviour study of electronic components. It identifies the flaws in design. The reliability and performance of electronic consoles after the drop is a major concern. Devices are expected to continue functioning after suffering a drop. The model is allowed to fall freely due to gravity load application. Drop test standard ...
P. Krastev, and B. Tracey
Neurometrix, Inc., Waltham, Massachusetts, USA
Nerve localization is important for applications in regional anesthesia. Localization is achieved by stimulating the nerve with an electric field produced by a current from a needle inserted into the body of the patient, close to the target nerve. Modeling of the electric field in close proximity to the nerve may help to explain observed variations in threshold currents and can help to ...
A Method for Efficient Calculation of Diffusion and Reactions of Lipophilic Compounds in Complex Cell Geometry
Kristian Dreij, Qasim Ali Chaudhry, Bengt Jernström, Ralf Morgenstern, and Michael Hanke
Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
School of Computer Science and Communication, Royal Institute of Technology, Stockholm, Sweden
A general description of effects of toxic compounds in mammalian cells is facing several problems. Firstly, most toxic compounds are hydrophobic and partition phenomena strongly influence their behaviour. Secondly, cells display considerable heterogeneity regarding the presence, activity and distribution of enzymes participating in the metabolism of foreign compounds i.e. bioactivation ...