Dynamic Simulation of Bone Morphogenetic Protein Patterning in a 3D Finite-Element Model of the Danio Rerio Embryo
D. Umulis, and S. Lee
West Lafayette, IN
Zebrafish development of the dorsoventral axis relies on the spatiotemporal distribution of Bone Morphogenetic Protein (BMP) signaling, which is regulated by numerous secreted molecules such as Tolloid, Sizzled, and Chordin. The rich dorsal/ventral patterning network must achieve both spatial precision in the patterning of downstream targets and confernspatial precision at distinct time points in ...
A. Candeo and F. Dughiero
Department Electrical Engineering, University of Padova, Padova, Italy
Radiofrequency Ablation (RFA) represents a valid alternative for treating liver metastases in medically complicated patients. Conventional devices currently operate at 500 kHz, due to good conducting properties of tissues. However, the use of lower frequencies (i.e. 20 kHz) has been recently reported to enhance the treatment effectiveness, due to a more pronounced difference in electrical ...
G. Long, D. Plescia, and P. Shires
Ethicon Endo-Surgery, Cincinnati, OH, USA
Thermal ablation of malignant tumors has been conducted in patients who are not candidates for surgery for more than ten years. Recently it has been shown that low energy DC pulses can cause cell necrosis. An undesirable characteristic of DC pulses in-vivo is the stimulation of skeletal muscle. The intensity of the contraction depends in part on the duration and height of the pulse. Through the ...
Y. Song, and C. Wang
Florida International University, Miami, FL, USA
Enzymatic biofuel cells (EBFCs) are miniature, implantable power sources, which use enzymes as catalysts to perform redox reaction with biological fuels such as glucose. In this study using COMSOL Multiphysics, we use an EBFC chip, having three dimensional, highly dense micro-electrode arrays, fabricated by C-MEMS micro-fabrication techniques. Glucose oxidase (GOx) is immobilized on anodes for ...
A. Grünbaum, S. Petersen, H.W. Pau, and U. van Rienen
IEF funded by DFG Research Training Group 1505/1 Welisa, University of Rostock, Rostock, Germany
Otolaryngology “Otto Körner”, University of Rostock, Rostock, Germany
Modeling of 2-5 μm thin membranes into a cochlea with a width of 2 cm is computationally. The paper is focused on two approximative methods used to overcome this problem and in addition a simple model challenging of a plate capacitor with a thin membrane of different thickness in-between is presented. The results of simulations with both thin layer approximation methods are compared with those ...
Three-Dimensional Finite Element Modeling of Current Density in Maternal Transthoracic Defibrillation
A. Jeremic, J. Potts, E. Khosrowshahli
McMaster University, Hamilton, ON, Canada
McMaster University Hospital, Hamilton, ON, Canada
Although the cardiac arrest in pregnancy is a rare event it can have significant impact in terms of age of mother, mortality of unborn children and consequently long-term effect. One of the commonly used procedures in resuscitation is defibrillation. With recent advances in understanding pathophysiologies in pregnant women it became more obvious that previous studies should be extended to ...
N. Mane, A. Gaikwad
Department of Instrumentation, Cummins College of Engineering, Pune, Maharashtra, India
Micro electro-mechanical system (MEMS) is rapidly growing area of interest for a broad spectrum of applications. One particularly fast-growing area is biomedical applications for micromaching technologies. One application of interest to the biomedical industry is the development of microneedles. MEMS technology brings new means for biomedicine field. Patch-based transdermal drug delivery offers ...
A. Di Carlo, V. Sansalone, A. Tatone, and V. Varano
Modelling and Simulation Lab, Università Roma Tre, Roma, Italy
Laboratoire de Mécanique Physique, Université Paris Est, Paris, France
DISAT, Università degli Studi dell’Aquila, L'Aquila, Italy
We present a mechanical model a growing spherical shell suitable for predicting the evolution of a Saccular Cerebral Artery Aneurysms (SCAA). It relies basically on the Kröner-Lee decomposition, used to describe the interplay between the current and the relaxed configuration of body elements. Rupture or stabilization of a SCAA are the end effect of a number of biological mechanisms, still poorly ...
A. Kahlig, J. Hansmann, H. Walles, and T. Hirth
University Stuttgart, Institute for Interfacial Engineering, Stuttgart, Germany
Fraunhofer-Institute for Interfacial Engineering and Biotechnology (IGB), Stuttgart, Germany
For the development of bioreactor systems, it is reasonable to develop working simulations, to avoid a lot \"trial-and-error\" experiments. Our research goal is the creation of functioning bone grafts for transplantation. Therefore stem cells get homogenously seeded into porous ceramic scaffolds. To evaluate the needed parameters, like perfusion pressure or the mechanical deformation of the ...
B. Jordan, and P. Müller
The specification of cell types and morphogenesis of many biological systems are regulated by the concentrations of signalling molecules. Many systems employ a pair of secreted short-range activators and long-range inhibitors, and these are widely used to generate complex patterns during development. However, the biophysical mechanisms that regulate the different ranges of activators and ...