B. Jordan, and P. Müller
The specification of cell types and morphogenesis of many biological systems are regulated by the concentrations of signalling molecules. Many systems employ a pair of secreted short-range activators and long-range inhibitors, and these are widely used to generate complex patterns during development. However, the biophysical mechanisms that regulate the different ranges of activators and ...
C. Morgan, N. Kenkare, M. Williams, A. Peterson, and D. Williams
Alcon Eye Care Division of Novartis R&D, Duluth, GA
Alcon Eye Care Division of Novartis R&D and Georgia Institute of Technology Co-op Program, GA
Introduction of silicone hydrogel contact lens materials provided products of unprecedented capability to deliver oxygen to the eye during wear. One additional material characteristic of interest is the material’s permeability to ions. This paper discusses descriptive tools and optimization of an impedance method of characterizing ion permeability. A physical model of conductive paper with ...
S. Raveendran, S. Sukuvihar, S. Kumar, and T. Maekawa
• Bionanotechnology is a stream of modern science that deals with the study of biotechnology & nanotechnology applications. • Drug delivery applications as a key area of research attains more critical approaches where the role of nanoparticles are inevitable. • Biocompatible, non-cytotoxic hybrid mauran- chitosan nanoparticles has been synthesized and the drug release kinetics were ...
N. Mane, A. Gaikwad
Department of Instrumentation, Cummins College of Engineering, Pune, Maharashtra, India
Micro electro-mechanical system (MEMS) is rapidly growing area of interest for a broad spectrum of applications. One particularly fast-growing area is biomedical applications for micromaching technologies. One application of interest to the biomedical industry is the development of microneedles. MEMS technology brings new means for biomedicine field. Patch-based transdermal drug delivery offers ...
V. Tidwell, P. LaRosa, M. Zhang, H. Eswaran, A. Nehorai
Department of Electrical & Systems Engineering, Washington University in St. Louis, St. Louis, MO, USA
Monsanto Company, Technology Pipeline Solutions, St. Louis, MO, USA
OB/GYN Department, University of Arkansas for Medical Sciences, Little Rock, AR, USA
Uterine contractions during pregnancy are currently poorly understood – experts disagree on the mechanisms by which contractions propagate through the organ and the structural layout of the uterine muscle fibers. We have developed a multi-scale model of the uterus, at the cellular, tissue, and organ levels. By comparing simulated abdomen-level magnetic field readings from our model to clinical ...
A. Di Carlo, V. Sansalone, A. Tatone, and V. Varano
Modelling and Simulation Lab, Università Roma Tre, Roma, Italy
Laboratoire de Mécanique Physique, Université Paris Est, Paris, France
DISAT, Università degli Studi dell’Aquila, L'Aquila, Italy
We present a mechanical model a growing spherical shell suitable for predicting the evolution of a Saccular Cerebral Artery Aneurysms (SCAA). It relies basically on the Kröner-Lee decomposition, used to describe the interplay between the current and the relaxed configuration of body elements. Rupture or stabilization of a SCAA are the end effect of a number of biological mechanisms, still poorly ...
New York University, New York, USA
Computational models of biological systems are becoming more and more common in medical research areas. Evidence of this can be found by examining the number of articles containing the term “finite element” in the expansive National Institutes of Health (NIH) digital research archive PubMed. Numerical modeling of biological systems allows the execution of “computational ...
H.C. Wong, K.N. Cho, and W.C. Tang
Department of Biomedical Engineering, University of California, Irvine, California, USA
Atherosclerosis causes the deposition of plaque on the inner walls of arteries, which leads to restricted blood flow. Using the balloon angioplasty procedure, stents can be inserted and expanded in the atherosclerotic artery. We used COMSOL Multiphysics Structural Mechanics, Solid Stress-Strain module to perform static, large deformation analyses. Our results show that lower stent stresses were ...
Analytical Methods for Reducing the Number of Independent Parameters Required to Model the Vocal Folds
D. D. Cook1, E. Nauman1, and L. Mongeau2
1Department of Mechanical Engineering, Purdue University, West Lafayette, IN, USA
2Department of Mechanical Engineering, McGill University, Montréal, QC, Canada
Mechanical tissue properties are required for reliable numerical models of the vocal folds. In this study, criteria for determining the compatibility of tissue property values obtained from independent studies are presented.Two methods for reducing the number of independent material parameters are given. The errors introduced by these assumptions were quantified by performing a modal analysis on ...
R. Said, R. Cotton, P. Young, A. Datta, M. Elwassif , and M. Bikson
 Simpleware Ltd, Exeter, Devon, UK
 Department of Biomedical Eng., The City College of New York, New York, NY, USA
This paper will discuss the comprehensive solution adopted for converting the 3D digital/medical images directly into the computational model. The workflow using Simpleware Software – ScanIP and + ScanFE – will be illustrated including the option for directly exporting fully compatible models to COMSOL Multiphysics. The extra functionality that allows introduction, positioning and ...