Advancing Regulatory Science through Integrative Engineering with COMSOL Multiphysics® Software Modeling
G. Zhang 
 Department of Bioengineering, Institute for Biological Interfaces of Engineering, Clemson University, Clemson, SC, USA
The US Food and Drug Administration (FDA) faces significant challenges in its regulatory approval processes due to a lack of relevant science, and many practices are limited by laws enacted in the previous century . Therefore, in recent years, the FDA has identified the need for advancements in regulatory science and innovation. In a broader sense, advancing regulatory science is not just ...
S. P. Ruhela, V. Vinod, S. Kishore, B. K. Sreedhar, I. B. Noushad, B. Krishnakumar, P. Kalyanasundaram, and G. Vaidyanathan
 Fast Reactor Technology Group, Indira Gandhi Centre for Atomic Research, Kalpakkam, Tamil Nadu, India
Steam Generator Test Facility (SGTF) is set up in IGCAR to optimize the design of Steam Generators (SG) for Fast Breeder Reactors. In the SG of SGTF heat exchange takes place from sodium which enters at 525 ºC and leaves at 355 ºC temperature to the water/steam which enters at 235 ºC and leaves at 493 ºC. To reduce the steady state differential temperature and thermal shock during transients, ...
P. Lamy-Bracq and C. Coulouarn
Nexter Munitions, Tarbes, France
A solidification process of casting explosives in shell is studied in this paper. An enthalpy method approach is used to model the solidification process. Both the thermal and mechanical effects are taken into account. An ALE (Arbitrary Lagrangian-Eulerian) method is used to represent the physical deformation due to solidification. Results from the model are verified against experimental ...
Computation of the Longitudinal Dispersion Coefficient in an Adsorbing Porous Medium Using Homogenization
A. Rijnks, M. Darwish, and H. Bruining
StatoilHydro ASA, Bergen, Norway
Shell Exploration & Production International Centre, Rijswijk,
Section of Geoengineering, Faculty of Civil Engineering and Geosciences, TU Delft, Delft, The Netherlands
The method to derive upscaled expressions for the dispersion coefficients for reactive flow in a porous medium uses a periodic unit cell (PUC), which consists for instance of a spherical grain in a cube, but nothing prohibits defining more complex PUC's. Homogenization leads to a coupled system of equations where the flow is described by Stokes equation and the concentration fluctuation is ...
A. Schwen, G. Bodner, A. Schnepf, D. Leitner, G. Kammerer, and W. Loiskandl
Institute of Hydraulics and Rural Water Management, Univ. Natural Resour. Appl. Life Sci., BOKU, Wien, Austria
Institute of Agronomy and Plant Breeding, Univ. Natural Resour. Appl. Life Sci., BOKU, Wien, Austria
Institute of Soil Science, Univ. Natural Resour. Appl. Life Sci., BOKU, Wien, Austria
Modeling soil water dynamics requires an accurate description of soil hydraulic properties, i.e. the retention and hydraulic conductivity functions. Generally, these functions are assumed to be unchanged over time in most simulation studies. In this paper, we implemented temporal changes in the soil hydraulic properties in a Richards’ equation simulation of soil water dynamics. Based on ...
R. Dufour , C. Wu, F. Bendriaa, V. Thomy, and V. Senez
BioMEMS Group, IEMN, University of Lille Nord de France, Villeneuve d’Ascq, France
This paper presents an Analog to Digital Microfluidic Converter (ADMC) using passive valves and enabling the conversion of a continuous liquid flow into droplets for Electro-Wetting On Dielectric (EWOD) actuation. Valves calibration, geometry characteristics and losses reduction have been optimized using microfluidic application mode of COMSOL Multiphysics®.
E. Zanchini, and T. Terlizzese
Dipartimento di Ingegneria Energetica, Nucleare e del Controllo Ambientale, Università di Bologna, Bologna, Italy
The results of two thermal response tests recently performed on two vertical borehole heat exchangers (BHEs) are presented. The BHEs have the same cross section and a depth of 100 m and 120 m respectively. The evaluation of the thermal properties of the ground and grout are performed by a finite-element simulation method, developed through the software package COMSOL Multiphysics 3.4.
D. Lahaye, D. Cvoric, S. de Haan, and J. Ferreira
Delft Institute of Applied Mathematics, Department of Electrical Engineering, Mathematics and Computer Sciences, TU Delft, The Netherlands
Electrical Power Processing Unit Department of Electrical Engineering, Mathematics and Computer Sciences, TU Delft, The Netherlands
Fault Current Limiters (FCLs) are expected to play an important role in the protection of future power systems due to the rising levels of the short-circuit currents. The inductive FCLs, comprising magnetic cores and one or more dc and ac windings, are particularly interesting because they inherently react on the fault. The so-called open-core FCL configuration employs only one magnetic core for ...
A. Zugliano, R. Artoni, A. Santomaso, A. Primavera, M. Pavlicevic
Danieli & C. Officine Meccaniche, Italy
DIPIC - Universita di Padova, Italy
A simulation of the behavior of bulk solids continuously flowing through a silo with internal flow feeders has been performed by means of a dissipative hydrodynamic model. The results obtained by these calculations and those found experimentally agree, not only with regard to the velocity profiles, but also relative to the pressure on the silo walls. The dissipative hydrodynamic model represents ...
T. Chen, and P.G. Ifju
University of Florida, Gainesville, Florida, USA
This paper describes using thermal-structural interaction to model the shrinkage behavior in cement paste under drying. An inverse method of combining the finite element analysis and the least-squares method is implemented to fit experimentally determined shrinkage in order to obtain material properties from the complex geometry used in the tests. The finite element model is created using COMSOL ...